EATRIS is a distributed European infrastructure for translational medicine. In 2019-2020, EATRIS participated in the piloting exercise of the RI-PATHS project. This pilot enabled EATRIS to make a first attempt at defining its impact pathways and explore ways to collect data evidencing its impact. This consulting project aims to refine the initial thinking on EATRIS impact through the identification of main impact pathways. The result of the project is a comprehensive socio-economic impact framework of EATRIS and a set of core indicators that are needed to trace evidence along the main impact pathways.